Chemical name :
CAS No. :98-92-0
Formula weight：formula weight
Nicotinamide, also known as nicotinamide, vitamin B3, or vitamin PP, is a water-soluble vitamin belonging to the B group of vitamins. It is a component of coenzyme I (nicotinamide adenine dinucleotide, NAD) and coenzyme II (nicotinamide adenine dinucleotide phosphate, NADP). In humans, the nicotinamide portion of these two coenzyme structures has reversible characteristics of adding Chemicalbook hydrogen and dehydrogenation, and plays a hydrogen transfer role in biological oxidation, It can promote tissue respiration, biological oxidation processes, and metabolism, and is of great significance for maintaining the integrity of normal tissues, especially the skin, digestive tract, and nervous system. When lacking, the respiration and metabolism of cells are affected, causing pellagra. Therefore, this product is mainly used to prevent and treat pellagra, stomatitis, glossitis, etc.
Nicotinamide is a white needle shaped crystalline or crystalline powder, odorless or slightly odorous, with a slightly bitter taste. Relative density 1.4, melting point 129-131 ℃. 1g of this product is soluble in 1mL of water, 1.5mL of ethanol, or 10mL of glycerol, but not in ether. The pH of 10% aqueous solution is 6.5-7.5. Has weak hygroscopicity. It is relatively stable and can withstand acid, alkali, and high temperatures. It is stable to light and heat in dry air, and generates niacin when heated in alkaline or acidic solutions. Rat oral LD502.5-3.5g/kg, with no special provisions for ADI values
The natural world mainly exists in the husks of grains, yeast, peanuts, meat, animal organs, dairy products, and green leafy vegetables. In the human body, tryptophan Chemicalbook acid can be synthesized, but the efficiency is extremely low.
Escherichia coli (Escherichiacoli) in the intestine can synthesize nicotinic acid and then convert it into nicotinamide